[Fis] Molecular recognition and the foundamental laws of information: relationship between the two parts and the hierarchical levels

From: Dr. Shu-Kun Lin <[email protected]>
Date: Tue 22 Jul 2003 - 14:19:29 CEST

Dear FISers,

Let us consider the relationship between the two parts (most cases pair-wise)
of a molecular recognition. We may put them as a binary system. For the list
prepared by Pedro, one part (host or guest) is taken as 0, the other is 1. If all of us
can agree, we are ready to do quantitative calculation of the molecular
recognition using information theory concepts.

It becomes more complicated if we go further: One of the 2 DNA threads are
complementary to each other. We can take one thread as 0, the other 1.
After their pairing (molecular recognition) the double helix is more symmetric
and information become less (2 bits goes to 1 bit) and more stable.
at this hierarchical level.

At lower hierarchical level (more microscopic level),
4 heterocyclic bases, adenine (A), guanine (G), cytosine (C) and thymine (T)
can be considered as a unit. Then, there are many more "molecular recognition" locations.
Still at this level, in more detail, we may define every atom as a
"molecular recognition" location.

At a much higher hierarchical level (more macroscopic level), man (0) and woman (1)
who carry the genetic material DNA having sex (recognition
at the higher hierarchical level) can be considered as a partner recognition.

Information theory concepts applied to discuss interactions are practically
useful at all the hierarchical level. It is useful for assessing the stability at
the concerned hierarchical level (certain microscopic or macroscopic levels).
Therefore the consideration of one hierarchical level to another on the
whole spectrum of all kinds of microscopic or macroscopic levels can be possible.
I have been interested in a theory which can be used to both macroscopic
and microscopic levels and intermediate levels which is different
from equilibrium or nonequilibrium thermodynamics.

Shu-Kun

--
Dr. Shu-Kun Lin
Molecular Diversity Preservation International (MDPI)
Matthaeusstrasse 11, CH-4057 Basel, Switzerland
Tel. +41 79 322 3379, Fax +41 61 302 8918
e-mail: lin@mdpi.org
http://www.mdpi.org/lin
_______________________________________________
fis mailing list
fis@listas.unizar.es
http://webmail.unizar.es/mailman/listinfo/fis
Received on Tue Jul 22 14:15:15 2003

This archive was generated by hypermail 2.1.8 : Mon 07 Mar 2005 - 10:24:46 CET