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The potential role of agrmediated quorum sensing is not as clear in other
host environments. We and other researchers have shown through in vivo human
and animal studies that agr appears to be unnecessary in certain infections
for the expression of secreted virulence factors For example agr expression
in a rabbit abscess model was decreased at the same time that the animals
developed TSS through exotoxin production In addition an agr mutant was just
as effective at causing TSS as the isogenic wildtype organism. psyns 15
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Received on Thu Nov 4 00:11:42 2004


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